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2010•Animal husbandry and feed scienceRequires access

Molecular Mechanisms of Maintaining Self-renewal of Embryonic Stem Cell

Guifeng Wang

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Abstract

Regulation of self-renewal of embryonic stem cells(ES) is a complex molecular signaling system.When the signal system is in overall balance,the self-renewal of ES cells can be maintained.The ES cells can be applied and the downstream stem cell-based technology can be developed only after the function of these signaling pathways has been understood.The paper reviews the research progress in the molecular mechanism of self-renewal of ES cells by analyzing important cytokines such as LIF,Oct-4 and Nanog.

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What this paper is about

Regulation of self-renewal of embryonic stem cells(ES) is a complex molecular signaling system.When the signal system is in overall balance,the self-renewal of ES cells can be maintained.The ES cells can be applied and the downstream stem cell-based technology can be developed only after the function of these signaling pathways has been understood.The paper reviews the research progress in the molecular mechanism of self-renewal of ES cells by analyzing important cytokines such as LIF,Oct-4 and Nanog.

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Available abstract

Regulation of self-renewal of embryonic stem cells(ES) is a complex molecular signaling system.When the signal system is in overall balance,the self-renewal of ES cells can be maintained.The ES cells can be applied and the downstream stem cell-based technology can be developed only after the function of these signaling pathways has been understood.The paper reviews the research progress in the molecular mechanism of self-renewal of ES cells by analyzing important cytokines such as LIF,Oct-4 and Nanog.

Key concepts: Homeobox protein NANOG, Embryonic stem cell, Stem cell, Cell biology, Mechanism (biology), Function (biology), Biology, Signal transduction

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