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Molecular mechanisms on embryonic stem cell pluripotency

Pan Guangjin, Duanqing Pei

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Abstract

Derived from early embryo, embryonic stem (ES) cells have potential to self renew indefinitely and develop to any type of cells in human body (pluripotency). Several extrinsic signals such as LIF, BMPs and Wnt can support the self-renewal and pluripotency of embryonic stem (ES) cells through regulating the pluri- potent genes. In combination with intrinsic transcription factors such as FoxD3, Nanog, Oct4 , these factors form a regulatory network to support or limit each other's expression level, which maintain the properties of ES cells.

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What this paper is about

Derived from early embryo, embryonic stem (ES) cells have potential to self renew indefinitely and develop to any type of cells in human body (pluripotency). Several extrinsic signals such as LIF, BMPs and Wnt can support the self-renewal and pluripotency of embryonic stem (ES) cells through regulating the pluri- potent genes. In combination with intrinsic transcription factors such as FoxD3, Nanog, Oct4 , these factors form a regulatory network to support or limit each other's expression level, which maintain the properties of ES cells.

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Available abstract

Derived from early embryo, embryonic stem (ES) cells have potential to self renew indefinitely and develop to any type of cells in human body (pluripotency). Several extrinsic signals such as LIF, BMPs and Wnt can support the self-renewal and pluripotency of embryonic stem (ES) cells through regulating the pluri- potent genes. In combination with intrinsic transcription factors such as FoxD3, Nanog, Oct4 , these factors form a regulatory network to support or limit each other's expression level, which maintain the properties of ES cells.

Key concepts: Homeobox protein NANOG, Embryonic stem cell, Rex1, Cell biology, Stem cell, Biology, Wnt signaling pathway, Nanog Homeobox Protein

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