Literature Analysis of 21 Cases of Anaphylactic Shock Induced by Astragalus membranaceus Injection

OBJECTIVE:To discuss the characteristics and related factors of anaphylactic shock induced by Astragalus membranaceus injection, and to provide references for clinical drug use . METHODS: Retrieved from CNKI, CHKD, Wanfang database and VIP, 21 cases of A. membranaceus injection-induced anaphylactic shock reported in Chinese medical science journals during the period of 1995-2010 were collected. A related database was established for statistical analysis. RESULTS: Of 21 cases, 16 cases occurred in patients aged over 40 years, accounting for 76.19%; 11 were male (52.38%), 10 were female (47.62%); all were intravenous infusion. 14 patients suffered from anaphylactic shock after the initial administration (66.67%). Anaphylactic shock mostly occurred within 5 min after administration, and there were 8 cases (38.10%). CONCLUSION: Careful attention should be paid to the adverse drug reaction of anaphylactic shock induced by A. membranaceus injection in clinical practice to ensure safe drug use.