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Alcohol Metabolism & the Relative Genetic Polymorphism

JI Ke-liang

Abstract

The important enzymes for alcohol metabolism included alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH). The metabolic pathways of alcohol were as follows: alcohol oxidized into aldehyde, and then aldehyde oxidized into acetic acid. The genetic polymorphism of ADH was composed of ADH1,ADH2(1),ADH2(2)?ADH2(3),ADH3(1)and ADH3(2). The genetic polymorphism of ALDH was composed of ALDH1,ALDH2,ALDH3 and ALDH4.

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Key concepts: Aldehyde dehydrogenase, ALDH2, Alcohol dehydrogenase, Alcohol, Ethanol metabolism, Aldehyde, ADH1B, Enzyme