ScholarLens Back to search
2007•Chinese Journal of Cardiovascular ReviewRequires access

Effect of puerarin on the expression of Heat shock protein 70 on the myocardial ischemia/reperfusion in rats

Zhong Zhi-ying

Open publisher page 0 citations

Abstract

Objective To explore the effect of puerarin on the expression of heat shock protein 70 (HSP70) on the myocardial ischemia/reperfusion(I/R) in rats. Methods I/R rat model was established by ligation of the anterior branch of the left coronary artery. The HSP70 expression in myocardium was detected by SP method of immunohistochemistry.Results Compared with control groups , the contents of HSP70 of group Puerarin were significantly increased at 0.5,4 and 8 h after I/R(P0.01). Puerarin can decrease the serum concentrations of MPO(P0.01) at 0.5,4 and 8 h after I/R. Conclusion Puerarin can reduce myocardial ischemia reperfusion injury significantly. The myocardial protection of puerarin may be realized by increasing the expression of HSP70 and reducing the serum concentrations of MPO.

About this research paper

What this paper is about

Objective To explore the effect of puerarin on the expression of heat shock protein 70 (HSP70) on the myocardial ischemia/reperfusion(I/R) in rats. Methods I/R rat model was established by ligation of the anterior branch of the left coronary artery. The HSP70 expression in myocardium was detected by SP method of immunohistochemistry.Results Compared with control groups , the contents of HSP70 of group Puerarin were significantly increased at 0.5,4 and 8 h after I/R(P0.01). Puerarin can decrease the serum concentrations of MPO(P0.01) at 0.5,4 and 8 h after I/R. Conclusion Puerarin can reduce myocardial ischemia reperfusion injury significantly. The myocardial protection of puerarin may be realized by increasing the expression of HSP70 and reducing the serum concentrations of MPO.

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Objective To explore the effect of puerarin on the expression of heat shock protein 70 (HSP70) on the myocardial ischemia/reperfusion(I/R) in rats. Methods I/R rat model was established by ligation of the anterior branch of the left coronary artery. The HSP70 expression in myocardium was detected by SP method of immunohistochemistry.Results Compared with control groups , the contents of HSP70 of group Puerarin were significantly increased at 0.5,4 and 8 h after I/R(P0.01). Puerarin can decrease the serum concentrations of MPO(P0.01) at 0.5,4 and 8 h after I/R. Conclusion Puerarin can reduce myocardial ischemia reperfusion injury significantly. The myocardial protection of puerarin may be realized by increasing the expression of HSP70 and reducing the serum concentrations of MPO.

Key concepts: Puerarin, Hsp70, Medicine, Heat shock protein, Ischemia, Shock (circulatory), Myocardial ischemia, Internal medicine

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
Effect of puerarin on the expression of Heat shock protein 70 on the myocardial ischemia/reperfusion in rats — Research Paper | ScholarLens