Research of expression of co-receptor CD22 and CD72 on peripheral B lymphocytes in patients with Guillian-Barre syndrome

Objective To explore the expression of co-receptor CD22 and CD72 on peripheral B lymphocytes in patients with Guillian-Barre syndrome(GBS) and its corelation with GBS's cours and condition.Methods Thirty-six GBS patients(GBS group) were divided into acute subgroup and recovery subgroup,mild subgroup and severe subgroup according to course and pathogenetic condition.The expression of CD22 and CD72 were examined by flow cytometry,and the results were compared among subgroups,and compared with normal control group(20 cases).Results The B lymphocyte numbers in GBS group(606±118) was significantly higher than normal control group(248±92),and the positive cell ratio of CD72+CD19+ in GBS group [(62.11±9.14)%]was significantly decreased than normal control group [(69.72±11.42)%](all P0.01);the positive cell ratio of CD22+CD19+ was no significant differences in the two groups.In GBS group,B lymphocyte numbers in acute subgroup(682±91) was significantly higher than recovery subgroup(550±111),and the positive cell ratio of CD72+CD19+ in acute subgroup [(57.79±7.69)%] was significantly decreased than recovery subgroup [(68.14±7.58)%](all P0.01).The positive cell ratio of CD22+CD19+ had no significant difference in the two subgroups.In GBS group,B lymphocyte numbers in severe subgroup(685±116) was significantly higher than mild subgroup(561±96)(P0.01),and the positive cell ratios of CD72+CD19+ and CD22+CD19+ had no significant difference in the two subgroups.Conclusions The B lymphocyte numbers in GBS patients is significantly increased,and the expression of CD22 has no marked change;but the expression of CD72 is significantly decreased,especially in acute stage.