The effect of ondansetron's compound medication for treatment and prevention of postoperative nausea and vomiting caused by using the pain-killer fentanyl

Objective To observe the effect of ondansetran,dexamethasone and droperidol for prevention of postoperative nausea and vomiting(PONV)caused by using the pain-killer fentanyl. Methods One hundred and eighty patients considered to have I or II level of surgery were enrolled and divided into six groups randomly,each group 30 patients. The fundamental prescription for pain-killer was to use fentanyl 0.7～1.0mg plus physiological saline to dilute to 100 ml. The infusion speed was 2ml/h. The A group were injected dexamethasone 10mg through veins. The B group:dexamethasone 10mg plus droperidol 5mg contained in analgesia pumps.The C group:dexamethasone 10mg plus droperidol 2.5mg contained in analgesia pumps. The D group:dexamethasone 10 mg plus ondansetran 8mg.The E group:dexamethasone 10mg plus ondansetran 8mg plus droperidol 2.5mg contained in analgesia pumps. The F group (the comparative group) were injected physiological saline 5ml through veins. The PONV situations of patients for the postoperative 24 hours were observed and recorded. Results The formation rate of postoperative nausea and vomiting in group E was the lowest ,surpassing A group significantly (P0.05) and B ,C ,D ,F groups (P0.01) and achieved the anticipated treatment goal. Conclusion The compound medication of ondansetran,dexamethasone and droperidol can significantly reduce postoperative nausea and vomiting(PONV)caused by using the pain-killer fentanyl. Meanwhile it's safe and effective and is worth applying to clinical application.