Quantitative Study of the Cerebral Hemodynamics Using Multislice CT Perfusion Imaging in Normal Adult

Objective To explore the application of multislice CT perfusion imaging(MSCTPI) in normal adult cerebral hemodynamics.Methods Routine CT and MSCTPI were performed by selecting the basal ganglia slice and its adjacent slice in 32 normal adults.The contrast material was bolus injected through antecubital vein,while cine scans were performed for 50 seconds.These dynamic images were processed with the CT perfusion software package.Cerebral blood flow(CBF),cerebral blood volume(CBV) and mean transiting time(MTT) were measured within the specific regions of interest(ROI) of the brain,and quantitative analysis was performed.Results A gradient of perfusion between gray matter and white matter showed on MSCTPI in normal adults.The values of CBF and CBV were 60.97±9.51 ml/100 g ·min and 2.06±0.40 ml/100 g respectively in basal ganglia,15.01±3.42 ml/100 g·min and 0.94±0.14 ml/100 g wespectively in the white matter,and 23.45±3.96 ml/100 g·min and 1.19±0.29 ml/100 g respectively in gray matter.The longest MTT was in the white matter and the shortest was in the basal ganglia.MTT in the basal ganglia,gray matter and white matter were 2.18±0.45 s,3.01±1.07 s and 4.44±0.85 s respectively.Conclusion MSCTPI provided a new imaging method for measuring the cerebral hemodynamics.