Effect of bartroxobin on adhesion molecule expression in peripheral blood of patients with acute ischemic stroke

Objective:To observe the expression changes of adhesion molecules in peripheral blood leukocytes and serum soluble adhesion molecules in acute ischemic stroke after treatment with bartroxobin. Methods:Treatment group( n =8) was given bartroxobin (20 BU in 3 d) and other routine treatment;Control group( n =18) was similar to treatment group except for bartroxobin.The expression of CD11b,CD18,CD62L,CD54 on polymorphonuclear and monocyte were measured by flow cytometry, soluble ICAM 1 and VCAM 1 were measured by enzyme linked immunosorbent assay in consecutive patients[within 12,24,48 h( P 0.05) after stroke onset]. Results:Compared with control group, the mean fluorescence intensity of CD11b on polymorphonuclear decreased significantly in bartroxobin treatment group 48 h after stroke onset.No significant changes of CD11b expression on monocyte,CD18,CD62L,CD54 expression on polymorphonuclear and monocyte, serum level of soluble ICAM 1,VCAM 1 were detected. Conclusion:Decreasing adhesion molecule expression may not involve in the chief mechanism of bartroxobin in treatment of acute stroke.