Expression of cyclooxygenase-2 in human renal cell carcinomas and its relationship to cell proliferation

Objective To detect the expression of cyclooxygenase-2 (COX-2) in human renal cell carcinomas,and study its relationship to cellular proliferation.Methods Immunohistochemistry was performed by using avidin-biotin peroxidase complex procedure.Results The positive rate of COX-2 expression in renal cell carcinoma was 23/45.But there was no or weak expression in noncancerous tissues of kideny.Overexpression of COX-2 in renal cell carcinomas was related to its pathologic grading,clinical staging and history types ~(P ~0.005). Although expression of Ki-67 was found in all RCC,there was a faint stain in normal renal tissue.The expression of Ki-67 was closely related to the pathologic grading,clinical staging and history types ~(P ~0.005). There was a correlation between COX-2 and Ki-67.Conclusion The overexpression of COX-2 in renal cell carcinoma may play a crucial role in its pathologic grading,clinical staging,history types and cell proliferation in renal cell carcinoma.