Effect of Budesonide atomization inhalation in the treatment of inhalation pneumonia

Objective To observe the efficacy of Budesonide atomization inhalation in the treatment of aspiration pneumonia. Methods 42 cases of patients with aspiration pneumonia in the First People's Hospital of Xiaoshan District in Hangzhou City from January 2012 to June 2013 were selected and divided into treatment group(23 cases) and control group(19 cases) according to different treating methods. The control group was treated with routine therapies including oxygen therapy, anti-infection and nutrition support therapy; the treatment group was treated with Budesonide suspension aerosol inhalation on the basis of control group. The treatment efficacy between the two groups was observed; the PaCO2, PaO2, pH value, fasting blood-glucose between the two groups were compared. Results ①20 cases of total effective, 3 cases of nullity or progress were found in treatment group, the total effective rate was 86.96%; 15 cases of total effective, 4 cases of nullity or progress were found in control group, the total effective rate was 78.95%. The difference of total effective rate between the two groups was statistically significant(P 0.05). ②The difference of PaCO2before the treatment between treatment group and control group [(7.10±1.64) mm Hg vs(6.97±1.92) mm Hg](1 mm Hg=0.133 kPa) was not statistically significant(P 0.05); PaCO2level in treatment group 3 days after the treatment [(5.76±1.06) mm Hg] was lower than that in control group [(6.78±1.55) mm Hg], the difference was statistically significant(P 0.05); the difference of PaCO2between the two groups 1 week after the treatment was not statistically significant(P 0.05). ③The difference of PaO2before the treatment between the treatment group and control group [(8.10±1.52) mm Hg vs(8.21±1.23) mm Hg] was not statistically significant(P 0.05); PaO2level in treatment group 3 days after the treatment[(9.51±1.63) mm Hg] was higher than that in control group [(8.32±1.31) mm Hg], the difference was statistically significant(P 0.05); the difference of PaO2between the two groups 1 week after the treatment was not statistically significant(P 0.05). ④The difference of pH level between the two groups before the treatment and 3 days, 1 week after the treatment was not statistically significant(P 0.05). ⑤The difference of fasting blood-glucose between the treatment group and control group [(5.72±1.02) mmol/L vs(5.63±1.34) mmol/L] before the treatment was not statistically significant(P 0.05); the difference of fasting blood-glucose between the two groups 3 days and 1 week after the treatment was not statistically significant(P 0.05). Conclusion Budesonide in the treatment of aspiration pneumonia is safe and effective.