Evaluation Clinical Effect of Blood Purification in Pediatric Severe Pneumonia

Objective To evaluate clinical effect of blood purification in treatment of children with severe pneumonia.Methods This was a retrospective study with institutional ethics approval and written parents of each participating children consent.From January 2009to February 2013,a total of 51children with severe pneumonia admitted to West China Second University Hospital,Sichuan University were recruited.According to whether being given blood purification,they were divided into treatment group(n= 27)and control group(n=24).There had no significance difference between two groups among sex,age, pediatric critical illness score(PCIS)before treatment,rate of mechanical ventilation,and body temperature,breathing rate,heart rate,white blood cell(WBC)count,C-reactive protein(CRP),blood glucose,alanine transarninase(ALT),Na+and K+in blood,and result of blood gas analysis before treatment(P0.05).Mortality rate,hospital days,clinical situations and laboratory data before and after treatment for 5dwere analyzed by statistics.Results Mortality rate in treatment group was significantly lower than that in control group [40.7%(11/27)vs.70.8%(17/24),P0.05].After 5dtreatment, temperature and heart rate in treatment group were significantly lower than those before treatment [(37.13℃±0.71)℃vs.(37.94±1.34)℃,(121.63±21.16)/min vs.(151.11±29.31)/min;P0.05], which were lower than those in control group(P0.05).There had significance difference between two groups among serum Na+and K+abnormal rates(P=0.029,0.046),in treatment group that Na+and K+ abnormal rate which decreased after 5dtreatment fell to 20%(5/27)from 64%(16/27)and fell to 28%(7/ 27)from 48(12/27),respectively;but no change in control group[53.3%(8/24)]and while rised from 40%(6/24)to 60%(9/24),respectively.There had significance difference of CRP level in treatment group after 5dtreatment than that before treatment(P0.05);the PH value of arterial blood was rising after 5d treatment than that before treatment in control group(P0.05).There was no significance difference between two groups among WBC count,blood glucose,ALT,creatinine,blood urea nitrogen(BUN)and arterial carbon dioxide tension(PaCO 2)before treatment and after 5 d treatment(P 0.05). Conclusions Blood purification in treatment of pediatric severe pneumonia can get better results.More prospective studies are necessary to determine the effectiveness of blood purification in pediatric severe pneumonia.