2010•Modern Medicine HealthRequires access

Study on preparation and main drug content determination of baicalin liposomes

Shu-Yao Zhang

Abstract

Objective:To prepare and establish a method for the determination of baicalin liposomes.Methods:Baicalin liposome was prepared by reverse evaporating method,the content of baicalin in baicalin lipsomes was determined by HPLC.Results:The mean diameter and entrapment efficiency of baicalin lipsomes were 350nm and 60.1%.The linear range of baicalin was 0.29～1.45μg(r=0.9997) and the average recovery rate was 100.1%,RSD=0.2%(n=6).Conclusion:The preparation of baicalin lipsomes is simple and the content determination is simple,reliable and reproducible,which can be used in the quality control of baicalin lipsomes.

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Key concepts: Baicalin, Medicine, Liposome, Chromatography, High-performance liquid chromatography, Content determination, Biochemistry, Chemistry