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2004•Journal of Yangzhou UniversityRequires access

Pathological Observation of Pyramidal Cells in CA_1 Region of the Hippocampus After Reperfusion Following Forebrain Ischemia in Old Rats

Liu XueZhong

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Abstract

In order to observe the pathologic injures of pyramidal cells of CA_1 region in the hippocampus 3 d after reperfusion following 10 min forebrain ischemia, bilateral carotid arteries occlusion model of old rats were used and the changes of ultrastructure of pyramidal cells of CA_1 region in the hippocampus were observed with electron microscope; meanwhile, we observed the changes of pyramidal cells in CA_1 region of the hippocampus through Tunel (Terminal-deoxynucleotidyl transferase-mediated dUTP-biotin nick and labeling) staining. The results showed: Compared with the sham-group,the ultrastructure of pyramidal cells of CA_1 region in the hippocampus 3 d after reperfusion following 10 min forebrain ischemia showed apoptosis-like changes.it has been tested that Apoptosis may be an important form in the course of cerebral ischemia-reperfusion(IR) injury.

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What this paper is about

In order to observe the pathologic injures of pyramidal cells of CA_1 region in the hippocampus 3 d after reperfusion following 10 min forebrain ischemia, bilateral carotid arteries occlusion model of old rats were used and the changes of ultrastructure of pyramidal cells of CA_1 region in the hippocampus were observed with electron microscope; meanwhile, we observed the changes of pyramidal cells in CA_1 region of the hippocampus through Tunel (Terminal-deoxynucleotidyl transferase-mediated dUTP-biotin nick and labeling) staining. The results showed: Compared with the sham-group,the ultrastructure of pyramidal cells of CA_1 region in the hippocampus 3 d after reperfusion following 10 min forebrain ischemia showed apoptosis-like changes.it has been tested that Apoptosis may be an important form in the course of cerebral ischemia-reperfusion(IR) injury.

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Available abstract

In order to observe the pathologic injures of pyramidal cells of CA_1 region in the hippocampus 3 d after reperfusion following 10 min forebrain ischemia, bilateral carotid arteries occlusion model of old rats were used and the changes of ultrastructure of pyramidal cells of CA_1 region in the hippocampus were observed with electron microscope; meanwhile, we observed the changes of pyramidal cells in CA_1 region of the hippocampus through Tunel (Terminal-deoxynucleotidyl transferase-mediated dUTP-biotin nick and labeling) staining. The results showed: Compared with the sham-group,the ultrastructure of pyramidal cells of CA_1 region in the hippocampus 3 d after reperfusion following 10 min forebrain ischemia showed apoptosis-like changes.it has been tested that Apoptosis may be an important form in the course of cerebral ischemia-reperfusion(IR) injury.

Key concepts: TUNEL assay, Hippocampus, Ischemia, Forebrain, Pyramidal cell, Apoptosis, Ultrastructure, Terminal deoxynucleotidyl transferase

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Pathological Observation of Pyramidal Cells in CA_1 Region of the Hippocampus After Reperfusion Following Forebrain Ischemia in Old Rats — Research Paper | ScholarLens