The coagulation function and platelet's parameters in patients with chronic hepatitis B

Objective To explore the change and clinical significance of coagulation function index and platelet's parameters in patients with chronic hepatitis B.Methods 42 severe chronic hepatitis,24 acute-on-chronic liver failure,35 chronic liver failure,32 liver cirrhosis and 50 healthy peoples as control were collected.Their coagulation function index(PT,APTT,TT,Fig) and platelet's parameters(PLT,MPV,PDW,P-LCR) were detected.Results Compared with healthy group,MPV,PDW,P-LCR increased and PLT descended in various types of chronic hepatitis groups(P0.01);MPV,PDW,P-LCR were higher and PLT were lower in acute-on-chronic liver failure,chronic liver failure and liver cirrhosis groups than severe chronic hepatitis group(P0.01);PLT,MPV,PDW in acute-on-chronic liver failure group and MPV in chronic liver failure group were higher than those in liver cirrhosis group(P0.05,P0.01);There was significant difference in PLT between acute-on-chronic liver failure and chronic liver failure groups(P0.01);PT,APTT,TT were higher and Fig were lower in acute-on-chronic liver failure,chronic liver failure and liver cirrhosis groups than severe chronic hepatitis group(P0.01);Fig were lower in acute-on-chronic liver failure and chronic liver failure groups and APTT was higher in chronic liver failure group than those in liver cirrhosis group(P0.01).There was significant difference in APTT between acute-on-chronic liver failure and chronic liver failure groups(P0.01).Conclusion Coagulation and platelet parameters can reflect the degree of liver damage and bleeding tendency in patients with chronic hepatitis B.