The improving effect of high-fat enteral nutrition on nutritional status and clinical prognosis in acute stroke patients

Objective: To evaluate the effect of high-fat enteral nutrition on nutritional status and clinical prognosis in acute stroke patients. Methods: 56 cases of acute stroke patients were randomly divided into high-fat enteral nutrition(Supportan) group(high-fat group,28 cases) and standard enteral nutrition(Nutrison Fiber) group(control group,28 cases).All patients were treated by conventional therapy.The levels of blood glucose,hemoglobin,serum albumin,triglyceride,cholesterol,high density lipoprotein and low density lipoprotein,neurologic impairment score(NIHSS),and gastrointestinal side effects were measured before and at the 1st,the l0th,and the 21st day after enteral nutrition.Activity of daily living(ADL) was also observed at the 30th day after enteral nutrition. Results: The nutrition were not different between groups before EN.All nutrition indexes,except of blood glucose,were decreased at the l0th and the 21st day after enteral nutrition in control group.However,in high-fat group only the serum albumin level was decreased and the blood lipid level was maintained normally.The gastrointestinal side effects in two groups were not different.In high-fat group,NIHSS at the 21st day and ADL at the 30th day were markedly improved compared with those in control group(P 0.01). Conclusion: Early high-fat enteral nutrition support can significantly improve nutritional status and maintain blood lipid stability in patients with severe acute stroke,which is helpful for clinical prognosis.