Effect of CIK cell therapy on immune function of advanced lung adenocarcinoma patients

Objective To investigate the effect of cytokine induced killer cells treatment on immune function of patients with advanced malignant cancer. Methods Fifty-six patients with advanced malignant cancer who had been given chemotherapy and accepted the CIK treatment were collected. Peripheral blood monocyte cells( PBMCs) were isolated from blood samples of 56 cases.CIK cells were obtained from PBMCs which undergoing proliferation cultured in vitro. CIK cells were transfused to patients every other day,4 times a course,and for 3 courses. The changes before and after CIK treatment of T lymphocyte subsets and quality of life( QOL) were detected. Enzyme-linked immunosorbent assays( ELISA) was used to detect the changes before and after CIK treatment of IL-2 and IFN-γ. Results After treatment,the counts of T lymphocyte subsets such as CD3+,CD4+T cells and CD4+/ CD8+,the level of cytokine such as IL-2,IFN-γ were significantly higher than before( P all 0. 05). The counts of CD8+T was lower than before. However,there was no significant difference( P 0. 05). The remission rate of QOL was 69. 6%,which was significantly higher than before( P 0. 05). Conclusion CIK cells immunotherapy can improve the immunity and the quality of life of patients with advanced malignant cancer. CIK cells immunotherapy can be the ideal therapeutic strategy.