Correlation between up-regulation expression of Survivin and expression of Caspase-3 in gastric cancer tissues

OBJECTIVE:To discuss the correlation between the up-regulation expression of Survivin and the expression of Caspase-3 in gastric cancer,and to explore its roles in the carcinogenesis of gastric cancer.METHODS:The expressions of Survivin and Caspase-3 in 79 cases of gastric cancer and 30 cases of adjacent normal tissue were detected by using RT-PCR (reverse-transcription PCR).RESULTS:The positive expressions of Survivin and Caspase-3 mRNA in tumors were 46.8%(37/79) and 29.1%(23/79),respectively,and 16.7%(5/30) and 53.3%(16/30) in non tumorous pancreatic tissues respectively,and there were statistically significant differences in all(P0.01).The expression of Survivin mRNA was significantly related to the histological grade,depth of invasion,lymph-node metastasis and TNM stage (P0.05);the expression of Caspase-3 mRNA was significantly associted with the depth of invasion,lymph-node metastasis and TNM stage (P0.05).The expression of Survivin was positively correlated with Caspase-3 expression in gastric carcer (P0.01).CONCLUSION:Survivinin is the important factor that causes tumorigenesis of gastric cancer,while the up-regulation expression of Survivin may promote the progression of gastric cancer through inhibiting the expression of Caspase-3.