Analysis of pathogen infection and antibiotics sensitivity in patients undergoing biliary surgery

Objective To explore the clinical distribution and drug sensitivity of pathogen isolated from biliary tract infection of surgery, and to guide the rational use of antibiotics. Methods The clinical data of 464 patients, whose bile samples were obtained in surgery to perform the bacteria culture and drug susceptibility test, were retrospectively analyzed. Results Of the 464 patients, 114 were found with positive bile culture. A total of 123 strains of bacteria were isolated, including 91 strains of gram negative (74.0%) and 32 strains of gram positive bacteria (26.0%). The most common bacteria were E. coli, Enterococcus, Klebsiella pneumonia, Bacillus cloacae, Pseudomonas aeruginosa. Susceptibility test demonstrated that gram negative bacteria were sensitive to Carbopenems and gram positive bacteria were sensitive vancomycin. Conclusion Positive bile culture was closely related to biliary diseases. Broad spectrum antibiotics which was more effective to E. coli is recommended as the first choice for bile infection. If necessary, the combination use of antibiotics for gram positive bacteria was recommended.