Effects of Astragalus Injection on ALI in Rat with Hemorrhagic Shock and Endotoxin

Objective: To study the effects of Astragalus injection on acute lung injury(ALI) in rats with hemorrhagic shock and endotoxin.Method: Thirty-six male SD rats were randomly divided into physiological saline group(n = 12),low dose Astragalus injection group(n = 12),high dose Astragalus injection group(n = 12).Using the rat hemorrhagic shock and endotoxin attacking model,the normal saline group was given the gathering blood and twice of normal saline by the tail intravenous injection,the Radix Astragali low,the high dose groups was given the gathering blood and 10 g / kg,the 20 g / kg Astragalus injection by the tail intravenous injection.Rats were sacrificed and the lung was harvested and homonenized for the determination of tumor necrosis factor-a(TNF-a),interleukin-6(IL-6) and measure values of wet-to-dry lung weight ratio(W / D) at 2h after injection of LPS.Result: The determination of tumor necrosis factor-a(TNF-a),interleukin-6(IL-6) and measure values of wet-to-dry lung weight ratio(W/D) were higher in the control group than other groups.(P 0.01),compared with the control group,the high dose group were better than low-dose group.Conclusion: Astragalus injection has notable antagonistic effects on the ALI in the hemorrhagic shock and endotoxin rats,the high dose Astragalus injection is better than the low dose Astragalus injection.