Effectiveness and safety of high dose of Atorvasatin in treating hyperlipidemia in patients with coronary heart disease

AIM To evaluate the effectiveness and reliability of Atorvastatin in the treatment of hyperlipidemia.METHODS Eighty four cases with hyperlipidemia combined with coronary heart disease were randomized divided into two groups: Atorvastatin 80 mg/d in group A and Atorvastatin 20 mg/d in group B.The levels of TC,LDL-C,HDL-C,TG,ALT and CK in serum were examined before therapy,and 4 weeks and 12 weeks after therapy.RESULTS The levels of TC(P0.01) and LDL-C(P0.01) were significantly decreased in both groups but the dosage of 80 mg/d achieved better effect than the dosage of 20 mg/d.CONCLUSION Both the dosages of Atorvastatin 80 mg/d and 20 mg/d are effective and reliable in the treatment of hyperlipidemia.The dosage of Atorvastatin 80mg/d has better effect than the dosage of Atorvastatin 20 mg/d.