Comparison of the effect and dosage of propofol given by two infusion modes

Objective To compare the effect and dosage of propofol given by two infusion modes in patients undergoing gynecological laparoscopic operation.Methods 100 patients were randomly divided into two groups:target controlled infusion group(group I)and continue infusion group(groupⅡ).The target concentration of propofol in group I was set at 4μg/mL,and the induction dose in groupⅡwas 2 mg/kg.Patients were given fentanyl 4μg/kg and vecuronium 0.1mg/kg after consciousness extinction.The dosage of propofol infused according to auditory evoked potentials index(AAI)during anesthesia.The dosage of propofol was titrated keep AAI value about 20(between 15~25).The time of consciousness extinction,AAI value drops to 30,AAI value restores to 40 were recorded.The drop percentage of average arterial pressure(MAP)and the heart rate(HR)within 15 min after induction starts and the dosage of propofol consumed were also assessed.Results Compared with group I,the time of consciousness extinction and AAI value drops to 30 were significantly decreased in groupⅡ(P0.01),the drop percentage of MAP and HR within 15 min after induction starts were significantly increased(P0.05).The time of AAI value restored to 40 and dosage of propofol consumed were not significantly distinct between two groups.Conclusion The dosage of propofol and palinesthesia time are not increase with TCI.