Study on the correlation between hs-CRP and coronary heart disease as well as acute myocardial infarction

Objective To explore the relationship between high-sensitivity C-reactive protein (hs-CRP)and the occurrence of certain diseases such as coronary heart disease(CHD)and acute myocardial infarction(AMI).Methods Sixty-one CHD patients,45 AMI patients(patients group,excluding high hs-CRP level diseases caused by other etiological factors)and 35 healthy controls(control group)were enrolled in the study.The serum level of hs-CRP and myocardial zymogram was measured in the Hitachi 7060 automatic analyzer by latex-enhance immunoturbidimetry for all subjects,and cTnI of AMI group was detected with immunofluorescence method at the same time.The difference of hs-CRP level was compared and analyzed between control group and patients group;control group before and after treatment.Moreover,the relationship between hs-CRP and myocardial zymogram as well as cTnI was analyzed.Results The level of hs-CRP was significantly higher in patients group than that in control group(P0.01).There was statistical difference of hs-CRP level before and after treatment in control group(P0.01).hs-CRP was positively correlative with myocardial zymogram and cTnI.Conclusion The serum level of hs-CRP is significantly elevated in CHD and AMI patients, indicating the measurement of hs-CRP contributes to auxiliary diagnosis,therapeutic effect observation, and prognosis evaluation.