Survey and psychological intervention of depression state in patients with chronic hepatitis B

Objective To investigate the depression status in patients with chronic hepatitis B,and the effect of psychological intervention combined with drug on depression status.Methods Fifty-two patients with chronic hepatitis B were given a structural interview based on Hamilton depression scale and self-esteem scale.The patients with depression symptoms were treated with psychological intervention based on drug treatment.After 4 weeks,the two scales were determined again to evaluate the psychological states of the patients.Results Of 52 patients with chronic hepatitis B,49(94%)had depressive symptoms.Three factor[2(gender)×2(population)×2(before/after treatment)]ANOVA results showed that the main effect of psychological intervention was significant[F(1,45)=131.25,P=0.000];and that the interaction of psychological intervention and patient source was significant[F(1,45)=5.25,P=0.03].Conclusion After drug treatment and psychological intervention,the patient's depressive symptoms are relieved and the self-esteem level increases.Patients with chronic hepatitis B can achieve a better effect after targeted psychological interventions.