Effect of adjuvant treatment of noninvasive positive pressure ventilation in patients with acute cardiogenic pulmonary edema

Objectives To evaluate the effect of adjuvant treatment of noninvasive positive pressure ventilation in patients with acute cardiogenic pulmonary edema.Methods Twenty seven patients with acute cardiogenic pulmonary edema were given noninvasive positive pressure ventilation via face mask after hypoxia cannot be corrected by high-flow oxygen and conventional drug treatment.Clinical symptom,heart rate,breathing,arterial oxygen saturation and changes of arterial blood gas analysis were observed before and after the use of noninvasive positive pressure ventilation.Results Clinical symptoms and signs were obviously improved,oxygen partial pressure significantly increased [(90.08±15.39) mm Hg vs.(53.12±17.65) mm Hg,P0.05],partial pressure of carbon dioxide significantly declined [(14.52±20.52) mm Hg vs.(55.47±23.82) mm Hg,P0.05] in 20 cases(74.07%) out of the 27 patients with acute cardiogenic pulmonary edema after application of noninvasive positive pressure ventilation via face mask.Seven(25.93%) cases treated by orotracheal intubation and mechanical ventilation when noninvasive positive pressure ventilation failed.There were 2 dead cases.Conclusions Application of noninvasive positive pressure ventilation can significantly improve symptoms,signs and blood gas analysis results in patients with acute cardiogenic pulmonary edema.It can be used as one of the safe,rapid and effective adjuvant means of treatment on acute cardiogenic pulmonary edema.