The Role of Interleukin-17 and CRP in Patients with Chronic Obstructive Pulmonary Diseases

Objective:To investigate the role of interleukin-17(IL-17) and C-reactive albumin (CRP) in the pathogenesy of the chronic obstructive pulmonary disease (COPD). Methods:The serum levels of IL-17 and CRP were determined by double antibody enzyme-labeled immunosorbent assay (DA-ELISA) in 100 healthy control and 100 COPD patients at acute exacerbation phase and stable phase. Pulmonary functions of all research subjects were tested and calculated for the percentage of forced expiratory volume in one second (FEV1) of prediction value (FEV1%). Results:The serum levels of IL-17 and CRP were significantly higher in COPD patients with acute exacerbation than those of COPD patients at stable phase and healthy control (P 0.05). The serum level of IL-17 was negatively correlated with FEV1%(r = -0.437, P 0.05), and positively correlated with CRP(r = 0.582, P 0.05), in COPD patients with acute exacerbation phase. There was a positive correlation between the serum levels of IL-17 and CRP in COPD patients with stable phase (r = 0.481, P 0.05). Conclusion:IL-17 might be associated with pathogenesy of COPD. The serum levels of IL-17 and CRP can be used as the relevant indicators to monitor COPD.