Exploring dosage of sotalol on arrhythmia

Objective: To detect the efficacy and optimal dosage of sotalol on arrhythmia. Methods: 53 patients with non-myocardial infarction receiving sotalol with different string-does, were evaluated by clinic and 24-hour Holier monitoring. Results: (1) In all 53 patients, 39 cases were efficiency, the total effective rate was 73.58%. (2)In 39 efficacy cases, the average does was 93.57mg/d. (3)After oral low-does sotalol, QTc interval increased from (0.39±0.03) s to (0.41±0.03) s (0.01P0.05), HR decreased from (79.39±13.85) beats/min to (64.11 ± 8.19) beats/min(P0.01) But BP had no significant difference. (4) There were 9 cases had side effects, but all were alleviated by decreasing the dosage. No torsade de pointes. Conclusion: Sotalol was efficiency in treatment of supraventricular or ventricular arrhythmia.Its average efficient dose was low and its side effect was seldom. So it would become a better antiarrhythmic drug in future.