The expression of bFGF and microvessel density in non small cell lung cancer

Purpose:To investigate the relationship between the expression of basic fibroblast growth factor (bFGF), microvessel density (MVD) and the clinical pathology of non small cell lung cancer (NSCLC).Methods:The expression of bFGF and MVD were observed in 78 cases of NSCLC with immunohistochemical detection. Results:The expression of bFGF and MVD was greater in adenocarcinomas than in squamous cell carcinomas of NSCLC( P 0 05). The expression of bFGF was significantly different among the three groups of both squamous cell carcinomas and adenocarcinomas with varying differentiation ( P 0 05). There was higher bFGF expression and greater MVD in NSCLC patients with regional lymphnode involvement and those with later distant metastasis ( P 0 05) Conclusions:It suggested that the expression of bFGF and MVD is helpful in predicting the risk for metastasis and prognosis in NSCLC