The Expression and Correlation of bFGF in Non-smal1 Cell Lung Cancer

Objective To investigate the expressive significance of bFGF in non-smal1 cell lung cancer(NSCLC)and explore the correlation between the expression and tumor differentiation,staging or lymph node metastasis,and to elucidate the role of bFGF in tumor occurrence,invasion and metastasis of NSCLC.Methods The expression of bFGF in 80 cases of NSCLC and 40 cases of normal lung tissue was detected immunohistochemically by SP method.Results The positive rate of bFGF was higher in NSCLC group than that in normal lung tissue(P=0.000).In NSCLC,the expression of bFGF in staging Ⅲ-Ⅳ group was significantly different from the stagingⅠ-Ⅱgroup(P=0.000).The expression of bFGF in G3 group of NSCLC was also significantly different from G1-G2 group(P=0.013).The expression of bFGF in group with Lymph node metastasis was also significantly different from that in group without Lymph node metastasis(P=0.000).Conclusion The results indicate that bFGF may participate in the process of occurrance and progression in NSCLC.Detection of bFGF may be a effective parameter in evaluate occurrence,progression and prognosis of NSCLC,and may also have important clinical significance in early prediction of NSCLC.