Relation between vascular endothelial damage,platelet activation and acute coronary syndrome

Objective: To investigate the relation between vascular endothelial damage,platelet activation and acute coronary syndrome.Methods:A total of 40 patients with acute coronary syndrome served as study group,35 patients of stable angina pectoris as control group 1,and healthy volunteers in outpatient department as control group 2.CD62p,CD63,GP Ⅱ b / Ⅲ a receptor complex were determined by flow cytometry,FIB-C was determined by scattering turbidimetry,vWF and ET-1 were measured by ELASA,NO was determined by enzymic method,and endothelium-dependent vasodilation was measured by color Doppler.Results: vWF and ET-1 in study group were significantly higher than those of control group 1,control group 2(P0.05);NO and FMD were significantly lower compared with thoses of control group 1,control group 2(P0.05).CD62p,CD63,GP Ⅱ b / Ⅲ a receptor complex and the FIB-C in study group were significantly higher than those of control group 1 and control group 2(P0.05).Conclusions: Indexes of vascular endothelial damage and platelet activation change significantly in acute coronary syndrome patients,indicating that vascular endothelial damage and platelet activation have a relationship with acute coronary syndrome.