ANALYSIS OF CLINICAL AND PATHOLOGICAL FEATURES OF NASAL NK/T-CELL LYMPHOMA

[Objective]To discuss the clinical and pathological features,diagnosis and cause of misdiagnosis of the nasal NK/T-cell lymphoma.[Methods]he clinical data of 62 patients with nasal NK/T-cell lymphoma were reviewed about the clinical features and diagnosis. The formalin-fixed and paraffin-embedded biopsy specimens were analyzed by histopathology and immunohistochemistry.[Results]The main symptoms of nasal NK/T-cell lymphoma were nasal obstruction,epistaxis and headache,and presented with facial midline destructive lesion. The presentation of histopathology was that the neoplastic lymphoid cells scattered or diffused on the background of the coagulative necrosis and the multiple inflammatory cells. All cases were positively stained with T-cell marker,and negatively stained with B-cell by immunohistochemistry. Five cases were positively stained with NK cell.[Conclusion]The clinical manifestation of nasal NK/T-cell lymphoma is not typical,which is easy to be misdiagnosed and mistreated. The immunohistochemistry detection is an important method to diagnose. The T cell lymphoma is a major type of nasal NK/T-cell lymphoma.