2008•Jiepouxue yanjiuRequires access
Influence of amphetamine on behavior and serum levels of IL-2 of rats
SU Bao-gu
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Abstract
Objective To investigate the influence of amphetamine on behavior and serum level of IL-2 of rats. Methods Forty five mail SD rats (80～100 g) received intramuscular injection of amphetamine and were divided into low dose group (0.5 mg/kg), middle dose group(2.5 mg/kg) and high dose group(5.0 mg/kg). Fifteen rats were match as control group. Behavior changes were observed and score was evaluated according to Sams-Dodd method and serum level of IL-2 was measured by ELISA. Results ① Stereotyped behavior score showed no significant difference in control group compared to normal rats but was significantly higher in the experimental group than that of the control group (P0.05). ② Serum IL-2 level in the experimental group has no statistical significance compared to the control group. Conclusion Amphetamine has neurotoxicity on the experiment rats, but no significant inflluence on serum IL-2 level of rats