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Tumor multidrug resistance: mechanism and reversal agents

Caiguo Huang

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Abstract

Multidrug resistance(MDR) is one of the main obstacles limiting the efficacy of clinical chemotherapy treatment for tumors.Searching for highly effective and lowly toxic reversal agents for MDR is a hot field in regard to cancer drug development.The mechanisms of MDR mainly include P-glycoprotein,muhidrugresistance-associated protein,breast cancer resistance protein,1ung resistant-related protein,etc..MDR reversal agents include calcium channel blockers,Verapam and its derivative,etc..This paper mainly introduces the mechanisms of MDR and the development of MDR reversal agents.

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What this paper is about

Multidrug resistance(MDR) is one of the main obstacles limiting the efficacy of clinical chemotherapy treatment for tumors.Searching for highly effective and lowly toxic reversal agents for MDR is a hot field in regard to cancer drug development.The mechanisms of MDR mainly include P-glycoprotein,muhidrugresistance-associated protein,breast cancer resistance protein,1ung resistant-related protein,etc..MDR reversal agents include calcium channel blockers,Verapam and its derivative,etc..This paper mainly introduces the mechanisms of MDR and the development of MDR reversal agents.

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Available abstract

Multidrug resistance(MDR) is one of the main obstacles limiting the efficacy of clinical chemotherapy treatment for tumors.Searching for highly effective and lowly toxic reversal agents for MDR is a hot field in regard to cancer drug development.The mechanisms of MDR mainly include P-glycoprotein,muhidrugresistance-associated protein,breast cancer resistance protein,1ung resistant-related protein,etc..MDR reversal agents include calcium channel blockers,Verapam and its derivative,etc..This paper mainly introduces the mechanisms of MDR and the development of MDR reversal agents.

Key concepts: Multiple drug resistance, Drug resistance, Chemotherapy, Limiting, Mechanism (biology), Cancer, Medicine, Pharmacology

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