Risk Factors of Dementia after Cerebral Infarction and Therapeutic Effect of Donepezil

Objective To explore the risk factors of dementia after cerebral infarction,and to study the therapeutic effect of donepezil. Methods A total of 150 patients with cerebral infarction who admitted to The First People's Hospital of Shizuishan City,hospital from May 2009 to May 2012,were selected as study subjects,among whom 47 cases( 31. 3%) had dementia. The risk factors of dementia after cerebral infarction were analyzed by univariate analysis and multivariate Logistic regression analysis. The patients with dementia after cerebral infarction were divided into control group( 22 cases) and observation group( 25 cases),the control group was given conventional treatment,the observation group was given conventional treatment and donepezil hydrochloride tablets. After 9 months of follow-up,the therapeutic effect,cognitive function and activities of daily living were observed among patients with dementia after cerebral infarction. Results The dementia was related to age,degree of education,occupation,diabetes,smoking,hyperlipemia,hyperlipidemia and heart disease among patients with cerebral infarction( P 0. 05). According to Logistic regression analysis results,age,smoking,diabetes,and hyperlipidemia were the risk infactors for dementia after cerebral infarction and( OR = 1. 107、1. 961、1. 146、1. 148,P 0. 05). After 9 months,the therapeutic effect of observation group was better than that of control group( P 0. 05). After 6 months and 9 months of treatment,the scores of MoCA and MMSE in observation group were significantly higher than those in control group, the ADL score in observation group was significantly lower than that in control group( P 0. 05). Conclusion Advanced age, diabetes,smoking and hyperlipemia were risk factors for dementia after cerebral infarction. Application of donepezil on the basis of routine treatment can obviously improve cognitive function and life function,and has better long-term therapeutic effects.