Clinical observation of spironolactone treatment in patients with chronic heart failure of coronary heart disease

Objective To observe the effect of spironolactone treatment in patients with chronic heart failure of coronary heart disease. Methods 80 patients with chronic heart failure of coronary heart disease were randomly divided into therapy group (40 cases) and control group (40 cases).The patients in control group used mainly diuretil, angiotensin converting enzyme inhibitors( ACEI) , β - adrenoceptor blocking drugs and digitalis. On the basis of the above treatment, patients in therapy group used spironolactone instead of triamterene. Clinical effects were evaluated after three- month treatment. Results The total effectiveness of the therapy group was 92.5% , and the total effectiveness of the control group was 75.0% . There was distinctive difference between the two groups (P0.05). Conclusion Spironolactone can improve the clinical therapy effect obviously.