Study on the correlation between C-reactive protein and carotid atherosclerosis in patients with cerebral infarction

OBJECTIVE To study the value of serum C-reactive protein(CRP)level in patients with cerebral infarction and the relationship between them.To explore the clinical significance of CRP in the treatment of cerebral infarction.METHODS The clinical data of 112 patients with cerebral infarction were retrospectively analyzed in our hospital.The serum level of CRP on the third day was determined.The patients were divided into low CRP group and high CRP group based on the result.The neurological deficit score,the disability rate and the mortality rate after three months were calculated and compared.RESULTS The patients in low CRP group accounted for 42.86%,while 57.14% in high CRP group.Compared with that of high CRP group(19.14 ± 9.01),the neurological function deficit score in low CRP group was(10.48 ± 3.96),which showed significant difference(P﹤0.05);Compared with that in the high CRP group(73.44% and 23.44%),the rate of disability and mortality in low CRP group were 37.50% and 8.33%,which showed significant difference(P﹤0.05);The carotid artery IMT,internal carotid artery IMT and carotid artery plaque in the lower CRP group were(1.17 ± 0.14)mm,(1.07 ± 0.10)mm and 54.17%,respectively,while they were(1.29 ± 0.10)mm,(1.21 ± 0.09)mm and 85.94% in the high CRP group,which showed significant difference between two groups(P﹤0.05).101 plaques were detected in the low CRP group,while 219 in the high CRP group;The unstable plaques accounted for 57.43% in low CRP group,while the value in high CRP group was 38.81%,which showed significant difference between both groups(P﹤0.05).CONCLUSION The CRP monitoring in patients with cerebral infarction should be emphasized to effectively evaluate their symptom,and push the therapy correspondingly.