Intervention of participants with composite impaired glucose regulation and obesity by Metformin

Objective To observe the effects of intervention in participants with composite impaired glucose regulation and obesity by Metformin.Methods One hundred and sixty participants with impaired glucose regulation and obesity who were diagnosed by oral glucose tolerance test were randomly divided into control group and treatment group.Participants in control group received diabetic diet and physical training,and those in the treatment group were treated by Metformin sustained-releasing tablets(0.5 g,once every day) plus diabetic diet and physical training.Fasting plasma glucose(FPG),2hPG,body mass index(BMI),fasting insulin(FINS) and free fatty acid(FFA) were determined per 6 months during a follow-up period of 3 years for statistical analysis.Results The FPG,FINS,BMI,and FFA were markedly reduced after treatment in the treatment group(P0.05),and the 2hPG was reduced but had no statistically significant difference(P0.05).There was significant difference in each index in control group before and after treatment(P0.05).Condusion Metformin can prevent the development of impaired glucose regulation to type 2 diabetic mellitus by reducing the plasma glucose and BM,and improving the state of insulin resistance.Therefore,Metformin can prevent the morbidity of diabetes in the population with impaired glucose regulation and obesity.