Experimental Study on the Therapeutical Effect of Lang Qing A Ta on Hepatic Fibrosis

Objective:To study the therapeutical effect of Lang Qing A Ta(LQAT) on hepatic fibrosis induced by composite factors in rats.Method:The hepatic fibrosis model was induced by high fat and low protein feed combined with administration of ethyl alcohol and a subcutaneous injection of CCl 4in rats and the model rats were divided into five groups as model group,Fufang Biejia Ruangan table group and LQAT groups at three doses.The rats were orally treated with corresponding decoctions once a day for 7 weeks.The levels of biochemical indicators and hepatic fibrosis indicators in serum were detected,as well as the levels of hydroxyproline,superoxide dismutaso(SOD) and malondialdehyde(MDA) in liver.The histopathologic examination was proceeded to evaluate the pathological changes in livers.Result:LQAT decoction could remarkably decrease the liver coefficients and hydroxyproline contents of liver in hepatic fibrosis rats,decrease the levels of aspartate aminotransferase(AST),alanine aminotransferase(ALT),alkalinephosphatase(ALP),total bilirubin(T-BIL),hyaluronic acid(HA),laminin(LN),procollagen Ⅲ N-terminal peptide(PⅢNP),collagen type Ⅳ(CⅣ) and increase the levels of albumin(ALB) and alburmin/globulin(A/G) in serum.Furthermore,LQAT decoction could obviously increase the activity of SOD and decrease the MDA levels in liver.The results of histopathologic examination showed that LQAT at high and medium doses could ameliorate the pathological changes such as fibroplasia and inflammation and decrease the area of collagen fiber in livers.Conclusion:LQAT decoction has significant therapeutical effects on hepatic fibrosis in rats.