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Preventive effect of glutathione infusion combined with Ca/Mg on oxaliplatin-induced neurotoxicity

Yi Jun

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Abstract

Objective To observe the preventive effect of glutathione infusion combined with Ca/Mg on oxaliplatin-induced neurotoxicity.Methods The clinical data of 48 patients who received oxaliplatin-based combined chemotherapy were analyzed retrospectively.The treatment group was treated with glutathione infusion combined with Ca/Mg,and the control group without any preventive treatment.Results At the fourth cycle,5 patients in the treatment group,but 12 patients in the control group showed clinically evident neurotoxicity,which demonstrated the statistical difference between the two groups(P0.01).Conclusion Glutathione infusions combined with Ca/Mg can prevent oxaliplatin-induced neurotoxicity.

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What this paper is about

Objective To observe the preventive effect of glutathione infusion combined with Ca/Mg on oxaliplatin-induced neurotoxicity.Methods The clinical data of 48 patients who received oxaliplatin-based combined chemotherapy were analyzed retrospectively.The treatment group was treated with glutathione infusion combined with Ca/Mg,and the control group without any preventive treatment.Results At the fourth cycle,5 patients in the treatment group,but 12 patients in the control group showed clinically evident neurotoxicity,which demonstrated the statistical difference between the two groups(P0.01).Conclusion Glutathione infusions combined with Ca/Mg can prevent oxaliplatin-induced neurotoxicity.

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Available abstract

Objective To observe the preventive effect of glutathione infusion combined with Ca/Mg on oxaliplatin-induced neurotoxicity.Methods The clinical data of 48 patients who received oxaliplatin-based combined chemotherapy were analyzed retrospectively.The treatment group was treated with glutathione infusion combined with Ca/Mg,and the control group without any preventive treatment.Results At the fourth cycle,5 patients in the treatment group,but 12 patients in the control group showed clinically evident neurotoxicity,which demonstrated the statistical difference between the two groups(P0.01).Conclusion Glutathione infusions combined with Ca/Mg can prevent oxaliplatin-induced neurotoxicity.

Key concepts: Neurotoxicity, Oxaliplatin, Medicine, Glutathione, Chemotherapy, Pharmacology, Toxicity, Anesthesia

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