Expression of CD_(44)V_6 in invasive breast carcinoma and its relationship with prognostic significance

Objective To evaluate the relationship between CD_ 44V_6 and the prognosis in invasive breast carcinoma.Methods Comparison was made between 31 paitents with axillary node negative carcinoma and 25 patients with axillary node positive carcinoma for a minimum follow-up of 8 years.The level of CD_ 44V_6 (56 cases) expression was observed and compared with clinical and pathologic factors affecting prognosis and survival.Results Positive rate of CD_ 44V_6 expression was 80.4%.CD_ 44V_6 expression increased in node positive and high histologic grade patients.Conclusion Up regulation of CD_ 44V_6 expression correlates with malignancy of breast cancer.CD_ 44V_6 expression may serve as an important indicator of prognosis and guidance for clinical treatment.