2007•Journal of Beijing University of Traditional Chinese MedicineRequires access
Effect of Guizhishaoyaozhimu Decoction on IFN-γ and IL-4 in rats with collagen IIinduced arthritis
GU Li-gang
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Abstract
Objective To study the effect of Guizhishaoyaozhimu Decoction(GSZD) on rats with collagen Ⅱ-induced arthritis(CIA) and to discuss the mechanism.Methods The rat model of CIA was established and then the rats were given GSZD.After 21 days the weight and swelling of ankles were measured.The level of IL-4 in synovial membrane and serum was investigated with ELISA method.The activity of IFN-γ in synovial membrane and serum was investigated by release of NO-2 in mouse macrophage.Results The weight and swelling of CIA rats were relieved by GSZD.The level of IL-4 and the-activity of IFN-γ in synovial membrane and serum of CIA rats were down-regulated by GSZD.Conclusion The level of IL-4 and the activity of IFN-γ in synovial membrane of CIA rats were higher,and the activity of IFN-γ in serum was higher.GSZD has therapeutical effect on CIA rats,and one of its mechanisms may be regulating Th1/Th2 balance by decreasing IFN-γ and IL-4 in synovial membrane and serum.