Effect of Atorvastatin on Levels of H_2O_2,Malondialdehyde and Glutathione Peroxidase in Myocardium of Elderly Rats

Objective To investigate the content changes of H2O2,Malondialdehyde( MDA) and glutathione peroxidase( GSH-Px) in myocardium of elderly rats and the effect of Atorvastatin intervention on it. Methods A total of 90 Wister rats of 20 months old were randomly divided into elderly control group( group A,n = 30),high dose of Atorvastatin group[group B,10 mg /( kg·d),n = 30] and low dose of Atorvastatin group [group C,1 mg /( kg·d),n = 30]; another 30 Wister rats of 3 months old were chosen as young control group( group D). Rats in group B and C were lavaged with corresponding dose of Atorvastatin every day; rats in group A were lavaged with same volume of 0. 9% sodium chloride solution,and nothing was given to group D. After 4 months of intragastric administration,the myocardium samples were obtained,and contents of H2O2,MDA and GSH-Px in the four groups were respectively detected. Results Compared with those in group D,contents of H2O2and MDA in group A were significantly higher( P 0. 01),and GSH-Px liveness was significantly lower( P 0. 01). Compared with those in group A,the contents of H2O2and MDA were significantly lower( P 0. 05,P 0. 01),and GSH-Px liveness was significantly higher( P 0. 01); Compared with those in group D,the contents of H2O2and MDA were significantly higher( P 0. 05,P 0. 01),and GSH-Px liveness was significantly lower( P 0. 01); the changes in group B were more significant than those in group C( P 0. 05, P 0. 01). Conclusion Atorvastatin may significantly inhibit the changes of heart aging in elderly rats,which may be related with inhibition to the lipid peroxidation level.