Effect of tropisetron on preventing lung cancer patients from nausea and vomiting caused by chemotherapy

AIM: To observe the effect of tropisetron on preventing nausea and vomiting resulted from lung cancer chemotherapy. METHODS: One hundred and twenty patients with lung cancer who received the combined chemotherapy containing cisplatin were randomly divided into A,B groups and self contrast method was taken to observe the effects and toxicities of metoclopramide, tropistrion(5 mg)and granisetron(3 mg). RESULTS: The effect of tropisetron on preventing from nausea and vomiting resulted from chemotherapy was obviously superior to that of metoclopramide. The effective rate of metoclopramide and tropisetron in preventing nausea was 27 % ,23 % and preventing vomiting was 95 %, 93 % respectively. There was no obvious difference between the effective rate of granisetron and that of tropisetron.Their effect rates were 93 %,97 % in preventing nausea and 95 % ,92 % in preventing vomiting, respectively. Their adverse reactions were slight. CONCLUSION: Tropisetron is an excellent drug to prevent vomiting resulted from lung cancer chemotherapy. It is safe and cheap, and can be recommended widely to clinical use.