Pharmacokinetics of catechin in different formulations in rabbits

Pharmacokinetis of catechin were studied in 10 healthy rabbits following single intravenous(25 mg/kg) free and liposome catechin of the plasma. catechin concentrations were determined by high-performance liquid chromatography. The concentration-time data were fitted to a two-compartment model following a single intravenous injection in rabbits. The main pharmacokinetic parameters were as follows:distribution half-life(t 1/2α ) 0.15±0.01 h, elimination half-life(t 1/2β ) 0.58±0.02 h, apparent distribution volume(Vd) 2.97±0.11 L total body clearance(Cl B) 3.53±0.10 L/h, the area under curve(AUC) 16.95 ±1.52 mg/(L·h). The drug concentration-time data also were fitted to a two-compartment open model after a single intrarenous-catechin liposome. The pharmacokinetic parameters were as follows: t 1/2α 0.18±0.01 h, t 1/2β 1.52±0.08 h,V C 1.25±0.10 h, Cl B 2.05±0.01 mg/L, AUC 29.20±1.00 mg/(L·H).The results showed that the pharmacokinetic characteristics and tissue distribution of catechin were significant changes observed.