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2008•Chinese Journal of Hospital PharmacyRequires access

Effect of Kangxueshuan tablets on thrombogenesis and hemorheology in rats

Qing Lv

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Abstract

OBJECTIVE To study the effect of Kangxueshuan tablets(KXT) on the thrombosis of rats in vitro and blood viscosity in rats.METHODS To make the bypass between arteria cervicalis and vena cervicalis,and prepared the vitro-thrombus in rats by thread-embolism method.The thrombus of dry and wet weight were measured by weighting,plasma viscosity(PV) and blood viscosity were measured by Brookfield DV-Ⅲ+RHEOMETER rotational viscometer,and haemat(HCT) was detected by Sysmex kx-21 cytoanalyze.RESULTS The Kangxueshuan tablets could significantly reduce the weight of the thrombus and the blood viscosity in a dose-dependent manner.CONCLUSION The results showed that Kangxueshuan tablets could decrease the weight of the thrombus and improve the blood viscosity,and it might be the mechanism for treatment of cardio-cerebral vascular disease.

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OBJECTIVE To study the effect of Kangxueshuan tablets(KXT) on the thrombosis of rats in vitro and blood viscosity in rats.METHODS To make the bypass between arteria cervicalis and vena cervicalis,and prepared the vitro-thrombus in rats by thread-embolism method.The thrombus of dry and wet weight were measured by weighting,plasma viscosity(PV) and blood viscosity were measured by Brookfield DV-Ⅲ+RHEOMETER rotational viscometer,and haemat(HCT) was detected by Sysmex kx-21 cytoanalyze.RESULTS The Kangxueshuan tablets could significantly reduce the weight of the thrombus and the blood viscosity in a dose-dependent manner.CONCLUSION The results showed that Kangxueshuan tablets could decrease the weight of the thrombus and improve the blood viscosity,and it might be the mechanism for treatment of cardio-cerebral vascular disease.

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Available abstract

OBJECTIVE To study the effect of Kangxueshuan tablets(KXT) on the thrombosis of rats in vitro and blood viscosity in rats.METHODS To make the bypass between arteria cervicalis and vena cervicalis,and prepared the vitro-thrombus in rats by thread-embolism method.The thrombus of dry and wet weight were measured by weighting,plasma viscosity(PV) and blood viscosity were measured by Brookfield DV-Ⅲ+RHEOMETER rotational viscometer,and haemat(HCT) was detected by Sysmex kx-21 cytoanalyze.RESULTS The Kangxueshuan tablets could significantly reduce the weight of the thrombus and the blood viscosity in a dose-dependent manner.CONCLUSION The results showed that Kangxueshuan tablets could decrease the weight of the thrombus and improve the blood viscosity,and it might be the mechanism for treatment of cardio-cerebral vascular disease.

Key concepts: Hemorheology, Thrombus, Blood viscosity, Medicine, Plasma viscosity, Thrombosis, Viscometer, Viscosity

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