Study of effect of Bu Xu Hua Yu Fang (BXHYF) on immune suppression of carcinomatosis mice after chemotherapy

OBJECTIVE:To study the effect of Bu Xu Hua Yu Fang (BXHYF) on immune suppression of carcinomatous mice after chemotherapy. METHODS: The mice that were inoculated and feeded with BXHYF were devided into two dose groups:high dose group and low dose guoup. Meanwhile three control groups (normal group, carcinoma group and chemotherapy group) were included. CTX and Ara-c (both 150 mg/kg) were peritioneally injected into carcinomatous mice of high dose group, low dose group and chemotherapy group on the sixth and seventh day of being inoculated respectively.The influence of BXHYF on T cell subgroups of peripheral blood was observed by the flow cytometor analysis system. RESULTS:Chemotherapy markedly decreased CD + 4CD - 8 cell group and CD + 4/CD + 8 ratio, while CD - 4CD + 8 cell group increased obviously.High dose of BXHYF increased CD + 4CD - 8 cell group and adjusted CD + 4/CD + 8 ratio,P0.01.CONCLUSION: BXHYF can protect carcinomatous mice against immune suppression by CTX and Ara-c.