Anti-tumor Effect of Qishengheji and Its Influence on Myelosuppression Caused by Chemotherapy in S180 Tumor-bearing Mice

Objective To observe the effect of Qishengheji on myelosuppression caused by chemotherapy in S180 tumor-bearing mice.Methods Sixty mice were randomly divided into six groups,including normal control group,S180 control group,Cyclophosphamide(CTX) group,and high,medium and low dose of Qishengheji group.All mice except normal control group were vaccinated with S180 cells in armit of the right forearm,and administrated with corresponding drugs for 10 days.The administration groups were injected CTX intraperitoneally at 4th day after vaccination for 3 days.The normal control group and S180 control group were given NS.The peripheral blood routine,the inhibiting tumor rate and the weight of tumor were examined.Result Qishengheji improved the peripheral white blood cell(WBC) of S180 tumor-bearing mice with chemotherapy,the difference was significant compared with CTX group(P0.01).PLT was lower in CTX group and Qishengheji groups than that in S180 control group(P0.01).The tumor grew rapidly in S180 control group,and the weight of tumor in each dose of Qishengheji group and CTX group was lower than S180 control group(P0.01).There was significant difference between CTX group and medium dose of Qishegheji group(P0.01).CTX inhibited the growth of tumor,and the tumor inhibition rate was 49.69%.The tumor inhibition rate of high,medium and low dose of Qishengheji group combined with CTX was 60.55%,72.11% and 64.48%,respectively.Conclusion Qishengheji can enhance the efficacy and reduce the side effect of chemotherapy in S180 tumor-bearing mice.