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2004•Journal of Southeast UniversityRequires access

A novel azole antifungal:voriconazole

Shen Lan-hui

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Abstract

Voriconazole,a novel triazole antifungal,was developed in an effort to address the needs unmet by currently available antifungals.It has excellent in vitro activity against both Candida and Aspergillus species.And it showed a good antifungal activity against fluconazole-resistant,itraconazole-resistant species.The mechanism of action,in vitro activity,in vivo activity,pharmacokinetics,drug interactions,clinical trials,safety,and adverse effects of voriconzole,a novel antifungal,are reviewed in this paper.

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What this paper is about

Voriconazole,a novel triazole antifungal,was developed in an effort to address the needs unmet by currently available antifungals.It has excellent in vitro activity against both Candida and Aspergillus species.And it showed a good antifungal activity against fluconazole-resistant,itraconazole-resistant species.The mechanism of action,in vitro activity,in vivo activity,pharmacokinetics,drug interactions,clinical trials,safety,and adverse effects of voriconzole,a novel antifungal,are reviewed in this paper.

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Available abstract

Voriconazole,a novel triazole antifungal,was developed in an effort to address the needs unmet by currently available antifungals.It has excellent in vitro activity against both Candida and Aspergillus species.And it showed a good antifungal activity against fluconazole-resistant,itraconazole-resistant species.The mechanism of action,in vitro activity,in vivo activity,pharmacokinetics,drug interactions,clinical trials,safety,and adverse effects of voriconzole,a novel antifungal,are reviewed in this paper.

Key concepts: Voriconazole, Itraconazole, Fluconazole, Azole, Antifungal, Pharmacology, Triazole, Drug

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