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2004•Zhongguo linchuang yaolixue yu zhiliaoxueRequires access

Effects of 1-menthol and azone on percutaneous penetration of bifonazole in vitro

Huan Liu

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Abstract

AIM: To investigate the effects of penetration enhancer 1-menthol and azone on percutaneous absorption of bifonazole in vitro. METHODS: Percutaneous penetration experiment was performed on device in vitro and deposit effect was observed by vivo perception. Orthogonal function spectrophotomery was used for obliterating the interferance of absorption RESULTS: Azone (1 %) had a significantly effect on percutaneous absorp-tion of bifonazole. The lag times were shortened and the deposit effect was increased by azone. CONCLUSION: Azone can enhance the percutaneous absorption of bifonazole. Menthol can not enhance the percutaneous absorption of bifonazole, but it can increase the deposit effect.

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What this paper is about

AIM: To investigate the effects of penetration enhancer 1-menthol and azone on percutaneous absorption of bifonazole in vitro. METHODS: Percutaneous penetration experiment was performed on device in vitro and deposit effect was observed by vivo perception. Orthogonal function spectrophotomery was used for obliterating the interferance of absorption RESULTS: Azone (1 %) had a significantly effect on percutaneous absorp-tion of bifonazole. The lag times were shortened and the deposit effect was increased by azone. CONCLUSION: Azone can enhance the percutaneous absorption of bifonazole. Menthol can not enhance the percutaneous absorption of bifonazole, but it can increase the deposit effect.

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Available abstract

AIM: To investigate the effects of penetration enhancer 1-menthol and azone on percutaneous absorption of bifonazole in vitro. METHODS: Percutaneous penetration experiment was performed on device in vitro and deposit effect was observed by vivo perception. Orthogonal function spectrophotomery was used for obliterating the interferance of absorption RESULTS: Azone (1 %) had a significantly effect on percutaneous absorp-tion of bifonazole. The lag times were shortened and the deposit effect was increased by azone. CONCLUSION: Azone can enhance the percutaneous absorption of bifonazole. Menthol can not enhance the percutaneous absorption of bifonazole, but it can increase the deposit effect.

Key concepts: Azone, Bifonazole, Menthol, Chemistry, Penetration (warfare), Pharmacology, Chromatography, Medicine

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