Effect of carbon dioxide laser combined with imiquimod cream in the treatment of condyloma acuminatum in HIV/AIDS patients

Objective To observe the effect of carbon dioxide laser combined with imiquimod cream in treating condyloma acuminatum in HIV/AIDS patients with different levels of CD4+ T lymphocyte.Methods The design was case control study.The patients with condyloma acuminatum alone were treated as control group.The patients with both HIV/AIDS and condyloma acuminatum and CD4+ T lymphocyte 200 cells/μL were treated as group A.The patients with both HIV/AIDS with condyloma and CD4+ T lymphocyte 200 cells/μL were treated as group B.All patients were treated by carbon dioxide laser and imiquimod cream.Results Group A showed fewer recurrences of warts than group B.The difference was significant(P 0.05).Similar result was observed in the cure rate.The difference between groups was also significant(P 0.05).Conclusions Carbon dioxide laser combined with imiquimod cream was more effective in treating condyloma acuminatum and HIV/AIDS complicated with condyloma acuminatum when CD4+T lymphocyte level 200 cells/μL compared with the patients with CD4+T lymphocyte level 200 cells/μL.Treatment duration should be no shorter than 12 weeks in HIV/AIDS patients complicated with condyloma acuminatum and CD4+T lymphocyte level 200 cells/μL.When CD4+T lymphocyte level 200 cells/μL,the treatment duration should be longer than 12 weeks and HAART should be started early.Carbon dioxide laser and imiquimod cream treatment may be appropriate when CD4+T lymphocyte level recovered to 200 cells/μL.For the patients with both HIV/AIDS and condyloma acuminatum,carbon dioxide laser combined with imiquimod cream and HAART may be necessary when their CD4+T lymphocyte 200 cells/μL.